Detalhe da pesquisa
1.
Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion.
J Biol Chem
; 290(25): 15730-15745, 2015 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25931126
2.
Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes.
Bioconjug Chem
; 25(7): 1331-41, 2014 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24924618
3.
Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions.
MAbs
; 10(8): 1182-1189, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30252630
4.
CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models.
Mol Cancer Ther
; 17(1): 161-168, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29142069
5.
A simple LC/MRM-MS-based method to quantify free linker-payload in antibody-drug conjugate preparations.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1032: 144-148, 2016 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27311685
6.
Site-Specific Tandem Knoevenagel Condensation-Michael Addition To Generate Antibody-Drug Conjugates.
ACS Med Chem Lett
; 7(11): 994-998, 2016 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27882197
7.
Generating site-specifically modified proteins via a versatile and stable nucleophilic carbon ligation.
Chem Biol
; 22(2): 293-8, 2015 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25619935
8.
Exploring the effects of linker composition on site-specifically modified antibody-drug conjugates.
Eur J Med Chem
; 88: 3-9, 2014 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25176286